by turtleback
My wife and I really like this game with two. We have found you need to make two important rules changes to make the game work well with two.
1) Do not gain the victory point when entering Tokyo.
2) Only gain one victory point per turn stayed in Tokyo (as opposed to two).
We find this change makes staying in Tokyo way less attractive and makes the games closer.
We use the Power Up expansion too and love it.